Studies on activation of H3 histamine receptor: a mechanistic model.
نویسندگان
چکیده
The recognition and the activation mechanism of the H3 histamine receptor was studied based on quantum-chemical calculations. A mechanistic model proposed both for recognition and activation stage clarifies different properties of histamine and alpha-methylhistamine at the H3 receptor. Interaction with a hypothetical receptor sites leads to the opening of the intramolecular hydrogen bonding in histamine, whereas the alpha-methylhistamine remains in closed conformation.
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ورودعنوان ژورنال:
- Zeitschrift fur Naturforschung. C, Journal of biosciences
دوره 50 1-2 شماره
صفحات -
تاریخ انتشار 1995